Auditing- report of the real good food Assignment

Auditing- report of the real good food - Assignment Example Real Good Food PLC is a heavily diversified company that manufactures and distributes a variety of products like sugar, baking ingredients, dairy products, jam and sweet bakery products (Real Good Food PLC 2015). As it stands, the company owns the largest sugar distribution network in the United Kingdom. Real Good Food plc participates in various market sectors such as the wholesale, retail, manufacturing, food service and export. The company’s production and distribution activities are operated under six business divisions (Napier Brown, Real Good Food Europe, Renshaw, Garrett Ingredients, R&W Scott and Hayden Bakery) that supplies products to a greater part of the Eurozone (Annual Report: Real Good Food PLC 2014, pp. 1-3). The consumption of sugar worldwide has increased by more than 20% in the last ten years translating to an increase from around 140 million tonnes to 170 million tonnes currently consumed on an annual basis. The Eurozone consumption statistics show consumption rate of 16.5 million tonnes. The increase in sugar consumption rate presents a growth opportunity for Real Good Food PLC. However, it is feared that some major political factors may create a favourable situation for the exploitation of the opportunity. The whole world is getting sensitized to the health effects of sugar. Most nations, specifically in the west, seek to implement trade policies and health regulations that will set the standard of sugar contents in the manufactured products (Annual Report: Real Good Food PLC 2014, pp. 10). In addition, the production is affected by adverse weather conditions that have seen the global sugar production rate reduce. The prices of sugar are on the rise due to the reduction in the supply but increased demand. The economic performance, as measured by the market capitalization, of the sugar producing companies has declined due to the decrease in the stock prices. Fortunately, the

UV-Protective Effects of Soy Extracts in Cosmeceuticals

UV-Protective Effects of Soy Extracts in Cosmeceuticals UV-Protective effects of soy extracts in cosmeceuticals 1.0 Introduction Current changes in climate may have bothered many population of human around the globe. Thinning of ozone layer in the atmosphere aggravates the UV transmittance from the sun to the earth, which potentiate injurious skin effects when exposed to UV radiation [6]. The rising clinical cases of photo-induced skin problems covers from skin tanning until life-threatening skin cancer. Ultraviolet (UV) radiation, particularly UVB (280-320 nm) from sunlight is one of the main environmental hazards to cause skin damage [1]. Such exposure may lead to edema, erythema, hyperpigmentation, hyperplasia, photoaging, immunosuppression, sunburn, inflammation and mutations of skin [1,6]. In photoaging, it is marked by the presence of fine and coarse wrinkles, textural changes and loss of skin elasticity. One of the therapies which has been used, be it mythological or based on factual findings, is soy extracts. Soy isoflavones are composed of glucosides (daidzin, genistin and glycitin) and aglycone (daidzein, genistein and glycitein) which play a role in health benefits of soy. These two different isoforms exist naturally in the isoflavones [1]. Though both protein and isoflavone components contained in the soy may have variety in their health benefits, the most beneficial extracts of the soy are exhibited by isoflavones [4]. It has been demonstrated to possess the physiological effects of antioxidants, anti-inflammatory activities [1] and health-benefit in cardiovascular disease [4]. In regard to the UVB-induced skin damage, soy isoflavones prevent keratinocyte death. By suppressing UVB-induced intracellular H2O2 release, it also reduces oxidative stress in the body [1]. Plus, topical application of daidzein (an aglycone) effectively reduces the cancer occurrence induced by chronic solar UV radiation and it provides UV-protective antioxidant effects [2]. Application of genistein topically inhibits both initiation and promotion of skin tumour [5]. In short, soy extracts give a wealthy health advantages in terms of its UV-protective benefits onto the skin. The following review regards the action of soy isoflavone in exhibiting the UV-protective effects. 2.0 Mechanism of action Several different possible mechanism of action appeared to be responsible for the biological health of body, particularly on the skin. Majority of in vitro research to date has narrowed down the potential benefits of soy isoflavones into the effects of skin aging through anti-inflammatory effect of isoflavones and the effects of photocarcinogenesis through inhibition of cell proliferative activities. 2.1 Genistein inhibits COX-2 activities Irradiation of human skin fibroblasts by UVB lead to expression of Cyclooxygenase 2 (COX-2) level and Growth Arrest and DNA-damage inducible (Gadd45) gene, of which both are involved in inflammation process and DNA repair, respectively [2]. Cellular responses, such as aging and carcinogenesis are caused by COX-2 expression induced by UV radiation [11]. COX-2 is an enzyme responsible for inflammation and pain when there is an extrinsic stimulus acts against the body. Addition to non-steroidal anti-inflammatory drugs (NSAIDs), isoflavones also showed inhibitory effects on the COX-2 expression. In inflammation process, expression of UVB-induced COX-2 in human epidermal cell cultures is inhibited by genistein. Due to this anti-inflammatory profile, it supresses the prostaglandin E2 synthesis as stimulated by UVB [13]. Prostaglandin is a vital mediator to cause inflammation effect. Gadd45 gene is a regulator for cell cycle and a DNA repair gene. It functions as a stress sensor and subjected to strees-signaling responses, be it physiological or environmental stressors. Stressful conditions, such as ionizing radiation induce Gadd45 gene expression [7]. Consequently, this leads to cell cycle arrest, cell survival and senescence, DNA repair or apoptosis. The mechanism of Gadd45 protein coordinates the responses of cells towards the stressors is unclear [7]. 2.2 Glucoside combination proves more beneficial In a study conducted by Iovine et.al, treatment of UVB-induced DNA damage by using genistin or daidzin before irradiation did not show significant prevention of the damage. In other way around, treatment using glucoside combination of genistein and daidzin proved most effective protection against UVB-induced DNA damage [2]. This is also supported by another report by Iovine et al which showed that the combination of isoflavones (in this case is genistein and daidzein) proved more effectively in preventing DNA damage caused by UVB [7]. 2.3 Inhibition of tyrosine protein kinases and phosphorylation of EGF-receptor Phosphorylation of the epidermal growth factor receptor (EGFR) occurs as physiologic doses of UVB radiation are exposed to human keratinocytes [15]. Usage of isoflavone such as genistein blocks the action of tyrosine kinases (TPK) and phosphorylation of EGF-R, thus hindering the intracellular signalling pathway in human keratinocytes [9]. It is a potent tyrosine kinase inhibitor and may inhibit cell proliferation and differentiation [4]. Irradiation by UVB substantially initiates the phosphorylation of EGF-R and mitogen-activate protein kinase (MAPK) [10]. H202 plays a significant role in this process. UVB exposure to human keratinocytes generates H2O2, which mediates EGF-R phosphorylation [15]. This phosphorylation process can be inhibited by dose-dependently incubate or treat with genistein. TPK-dependent EGF-R phosphorylation and MAPK activation are related to the initiation of transcription factors (promoting activities); release of inflammatory mediators, for instance, prostaglandins; and stimulation of cell proliferation. UVB-activated EGF-R can also lead to an increase in the thickness of the epidermis [10]. Hence, the inhibitory effects of genistein to the UVB-induced EGF-R phosphorylation and MAPK activation suggests its potential anti-promotional effects [9]. However, the tyrosine kinase effects brought by genistein have been postulated to be irrelevant to its potential health advantages due to doses required to produce such effects [14]. 2.4 Blocks pyrimidine dimer formation UVB irradiation can initiate oxidative DNA damage represented by 8-hydroxy-deoxyguanosine (8-0HdG) and photodynamically-damaged DNA, as in pyrimidine dimer (PD) formation. 8-OHdG is a hallmark of carcinogenesis and aging and PD is a precursor of signature mutation of P53 genes. Formation PD and 8-OHdG in skin can be substantially promoted by UVB irradiation. Wei et al reported that in their study, UVB-exposed skins of euthanized mice were harvested for level of PD and 8-OHdG after the treatment with genistein. It was found that genistein significantly inhibited both PD and 8-OHdG formation in a dose-dependent regime [9]. In study conducted by Moore et al, pre-treatment of skin sample with dose-dependent regime of genistein prior to UV exposure can demonstrate a reduction in PD formation. An observable result can be seen in UV-induced DNA damage secondary to UV exposure in the absence of genistein after the treatment with genistein, whereby the damage has been significantly reduced in the skin sample [8]. Pharmacokinetics the isoflavone aglycone forms have poor solubility in water and oil; thus, a special galenic mixture is necessary to introduce these isoflavone preparations into cosmetic formulations [2]. Structure/medchem Genistein (4’,5,7-trigydroxyisoflavone) [7]

The Post-Soviet Reemergence of the Russian Empire Essay -- essays rese

The 1991 collapse of the Soviet Union signified an end to Russia’s control over its Middle Eastern Empire. Many of its states seceded and founded new nations and Russia lost significant power over the region. The new Russian Federation, in an effort to reestablish Soviet supremacy, has launched a neo-imperialistic campaign to once again have political, economic and security control over the area today known as the Caucasus. Principally, Russia wants to have political control over the area consisting of the lands of Azerbaijan, Kazakhstan, Turkmenistan, Georgia and Chechnya as well as the Caspian Sea. Furthermore, it is an objective to reap profit from this resource-rich area to stabilize Russia’s economy. Additionally, Russia wants to ensure the security of its power in the Middle East. In order to achieve these motives the Russian Government has used various strategies involving political legerdemain, economic exaction and military operations. After years of weakness following the breakdown of the Soviet Socialist government, Russia has once again sought to expand its empire over all of its successor states. The Russian government has used various tactics to assert power over the Caspian region as well as to achieve its political motives. Russia’s position in the economic sphere has been a valuable strategy to obtain political ends. â€Å"Moscow’s main lever of power, then as now, was its pipeline system, a remnant of the centralized Soviet economy in which all oil and natural gas from the Caspian first traversed Russia before passing on to the West.† (LeVinne, 1999) Russia’s control over this pipeline has meant that it has direct control over the Caspian nation’s resources and can use this to their advantage. One such example was... ...influence within the space of the former Soviet Union a determining aspect in the future of Russian statehood. The entities surrounding the Caspian Sea are also the focus of many vital economic prospects which would contribute to Russia’s hegemony over the Southern Tier region. In a textbook example of neo-imperialism Russia has covered all its bases included the impending threat of enemies resulting from Moscow’s political and economic exploitation. Russia has proved that it will use any means possible such as military conquest and political and economic hegemony to its advantage to extend its control over the territory, political systems and economic profits of the nations forming the Caucasus. The Russian government has certainly demonstrated its resurgent imperial ability and resolute determination to ultimately see the reemergence of a powerful Russian empire.

Discrimination in US Security

Is there systematic discrimination in government and private security organization? Discrimination is the biasness based on color, religion, race, age, sexual orientation, national origin and gender. There is systematic discrimination in government and private security organization especially among blacks and other minorities like the Muslims. Muslims and blacks according to government and private organization are perceived to be more capable of committing crime as opposed to people from other races.For example in 2001 after the September 11 hijackings an airport security firm in Washington was under fire for hiring seven Muslims women who were screeners. This was because among the seven women five were from Sudan which has been blacklisted by the U. S. government and private security organization, one was from Egypt and the other from Afghanistan which has been believed for years to be the hideout for Osama who the US government believe to be responsible for the 1998 bombing attack and 2001 and therefore is their enemy number one. Is racial profiling ever appropriate?Racial profiling is the act of using a person’s race or his characteristics of his ethnic background to determine his capability in committing a specific crime. It is inappropriate especially in matters of security as it allows crime to mushroom in certain races as the policemen tend to divert their attention to one particular race for example in airports, the screeners tend to scrutinize people from middle east origin and Asian origin more than the way they do it for the American citizens and European nationals. Also the United States policemen have been on several occasion accused of racial profiling the African Americans.In that when crime has been committed in a particular neighborhood, the first suspect is always an African American. Although racial profiling is only appropriate when the physical traits of the suspect has been given out for example hair color, body weight, complexion. This is the only circumstance that the policemen are allowed to racial profile because racial profiling always leads to injustice in the community in various occasions and the innocent ones are the ones who are always caught. (http//www. amnestyusa. org/racialprofiling/sevenfacts. html) Do you believe it is justifiable to take such actions to protect US national’s security?It is justifiable for US government to take such actions to protect US national security because it is a superpower country in world and as one she is the main target for terrorists as they want to bring it down because it is the only country that is brave enough to question the their action. The US government is allowed to discriminate in security organization and to racial profile because most of the terrorists like Osama are from Muslim origin and one fact that we know is that Muslims are very brave they can do anything and this is why we have suicide bombers.Also in US majoring of the criminals are blac ks because most of them do it to revenge on the misery they have gone through and discrimination. Most of them are illiterate as a result they can’t get a decent job and as a result the only option they have is to commit crime because even the music industry in US is flooded as we can not have everyone in the music industry. As a result the US government does all this to maintain peace and harmony in order to make united state a favorable and suitable environment for people to stay in and to work in. (http//www. amnestyusa. org/racialprofiling/sevenfacts. html) Reference Amnesty International U.S.A. Racial Profiling. Retrieved on January 8th 2008 from   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   http//www.amnestyusa.org/racialprofiling/sevenfacts.html

Square proposal

Rusk's Tasting Subject: Proposal to write a research paper on the impact of business communication problems of the employer's and the employees of Square Pharmacy along with a unique vision, higher mission and a goal orientation of that company Introduction The pharmaceutical industry in Bangladesh is the most developed technical regions within our financial system. This industry manufactures almost firebrands of medicines and they follow different forms for different medicines. This sector is providing 97% of the total medicine requisite of the local market.With the aim to expand into the export market, leading pharmaceutical companies are escalating their business. Square Pharmaceuticals Limited, the flagship company of Square Group, is holding the strong leadership position in the pharmaceutical industry of Bangladesh since 1985 and is now on its way to becoming a high performance global player. It is a trusted name in the industry of manufacturing quality medicines for more than four decade. SQUARE today symbolizes a name – a state of mind. It has today burgeoned into one of the top line conglomerates in Bangladesh.Certain reports suggests that Square is the FIRST to manufacture and market Modernization, Inclining and Catecholamine after the expiry of patents to export antibiotics and other ethical drugs overseas. O develop sustained release technology locally. To achieve an all-time industry high record sales turnover of US$ 25 million. To locally Decisional sodium in the chemical division. In addition to these Firsts, SQUARE Pharmaceuticals Limited (SSP) was always ahead in introducing new products in the market.Their sales turnover was more than Take 1 1. 46 Billion (IIS$ 163. 71 million) with about 16. 43% market share (April 2009- March 2010) having a growth rate of about 16. 72%. The major problem they are facing is communication problem between employees and employers within Square Pharmaceuticals Ltd. This problem has aroused because of not m aintaining a formal relationship between the employer and the employees. A well-managed business organization normally considers the employees as the vital foundation of efficiency gains.As it is a large organization so most of the times it has been seen that the top level employer gives orders to the lower level employees but they do not do their work and as they maintain a friendly relationship those top level managers cannot take adequate steps against them. Maintaining a friendly relationship within an organization is not a bad thing but sometimes the top level employers should behave in a formal way in order to make the employees work alongside the rules and obligations of the company's respected managers and employers.If this problem can be solved then they will give their best performance to enhance the organization. So basically we want to specialize in the communication problems regarding the employers and employees internally. Effective communication occurs only if the rec eiver understands the exact information or idea that the sender intended to transmit. Many of the problems that occur in an organization are the direct result of people failing to communicate. Therefore, we want to figure out the main problem in maintaining the formal relationship of this company's employers and employees within the organization.We want to do an in-depth analysis in order to figure out the communication problems and to find out their rational solutions. Every organization has a unique vision, a higher mission and a goal oriented with that company. We want to know the vision, mission and goals of this pharmaceutical. 2 Research Questions Does Square Pharmaceuticals have a business communication problem? If yes, then what type of business communication problems do they have? What are the reasons behind these communication problems? What are the impacts on that organization because of those communication problems?How can these problems be solved? What are the actions t hey are taking in order to solve those problems? Is there any possibility to ever solve those communication problems? If the problem be solved, what types of benefit will the organization get? Hypothesis The following hypotheses are developed for the study:HA : Technological changes may dad to communication problems. H2O: SAP software maybe more difficult to use than unfriendly to technological changes leading to communication problems. HA: The grapevine may break the hierarchy of information flow.HA: There maybe communication problems regarding changes in compensation and benefited structure. HA: There maybe communication problems regarding performance appraisal strategies. HA: Cultural differences may also cause difficulties in non-verbal communications, causing mixed messages. HA: Leaked confidential information creates a liability issue and may causes communication problem. HA: Communication problems may occurs due to employees who fail to listen or who don't know how to activel y listen to their colleagues.HI O: Negative and indifference attitudes amongst the employers and employees creates communication problems. 3 Research Methodology For our primary data we will survey on the employer and the employees of Square Pharmaceuticals Ltd. Through a questionnaire to find out their perception regarding this business communication problem and how it can be solved. Also we will interview one of the employers of that organization to know his/her opinion about hose problems and what actions should be taken in order to solve these matters.The secondary data of this report are collected from Square Pharmaceuticals and some other reports such as some well reputed newspapers articles; Daily Star, Dacha Tribune, then Journals and through browsing the internet. Organization Our research paper will follow the general format of a research paper with the main sections such as Introduction, Literature review, Methodology, Limitations, Data Analysis, Findings/Results of the r esearch, Discussion and Conclusion, References.Hence, the organization of this paper will be directed by the research questions which would be answered in the above mentioned main sections. Timetable We intend to follow the subsequent time schedule presented in the class in order to accomplish our research paper timely: June 24 : Final draft of the research proposal August 12: Submission of the research paper Request for Approval the valuable suggestions and instructions from you that will lead us towards our research about the silent killer: business communication problems of Square Pharmaceuticals Ltd. 4